A Unusual Case of Classic Hodgkin Lymphoma (cHL) with Aberrant T-Antigens Expression

Abstract Introduction/Objective T-cell-associated antigens (TCA) are rarely expressed by Hodgkin/Reed-Sternberg (HRS) cells of classical Hodgkin lymphoma (cHL) and is associated with uncertain clinical significance. Methods/Case Report We present a very recent case 68 year-old female no significant past medical history presented large right groin mass for 1 month. She denied any fever, night sweats, fatigue or weight loss. CT abdomen/pelvis showed inguinal/pelvic lymphadenopathy. Resection effaced nodal architecture vague nodular appearance large, atypical nucleolated in background small, mature lymphocytes histiocytes. Eosinophils conspicuously absent the background. The were polylobated lymphocyte histiocyte rich (L & H) like, classic HRS as well multinucleated appearance. morphologic features overlapped between Classic Lymphoma, Nodular Lymphocyte Predominant Lymphoma. Given immunohistochemical (IHC) neoplastic [CD45 negative, PAX5+ (weak), CD30+ (strong), CD15+ (majority) MUM1 +] diagnosis was most compatible CHL. Interestingly, subset (10-20%) aberrantly number T-cell markers (CD2, CD3, CD4, CD8). However, smaller T-cells did not show cytologic atypia aberrancies antigen markers. negative CD43 ALK1. TCR gamma gene rearrangement also clonal T-lymphocytes, thus excluding possibility peripheral Hodgkin-like cells. Based on morphology IHC profile, this proves to be CHL multiple TCA expression including CD2, CD4 CD8. planned chemotherapy. Four months after initial completion 2 cycles chemotherapy, her PET scan improvement inguinal adenopathy being size decreased avidity, indicating response treatment. due more cycles. Till todate she doing further symptoms. Results (if Case Study enter NA) NA. Conclusion So far reported cases (CHL) aberrant event-free survival overall when compared TCA-negative CHLs. Our finding contributes literature improves our knowledge disease.